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IL-33 Polyclonal Antibody

View printable datasheet for IL-33 Polyclonal Antibody

Printable Datasheet

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IL-33 Antibody for Western blot

>> See 3 other antibodies for IL33

Entrez Gene ID:

（Human） 90865

UniProt ID:

O95760

Details

Host / Isotype:	Rabbit
Class:	Polyclonal
Type:	Antibody
Species Reactivity:	Human （Hu） Murine （Ms） Rat （Rt）
Immunogen:	A 19 amino acid peptide from near the center of human IL-33.

Ordering Information
Pierce IL-33 Polyclonal Antibody
Product Number	Pkg. Size	Price	Purchase

PA5-20398	100 ug		Purchase ?

Storage:	Stored at -20oC, avoid repeated freeze thaw cycles
Form:	100 ug of affinity chromatography purified antibody （1 mg/ml） in PBS containing 0.02% sodium azide.

Applications	Dilution *

Western Blot （WB）	1 ug/ml
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Product Specific Information

PA5-20398 targets IL-33 in WB applications and shows reactivity with Human, Murine, and Rat samples.

The PA5-20398 immunogen is a 19 amino acid peptide from near the center of human IL-33.

General Information

Interleukin-33 （IL-33） is a recently identified member of the IL-1 family of cytokines whose other members include IL-1-a/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein （IL-1RAcP）. Receptor binding of IL-33 activates NF-kappa-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.

Product Images

Filter : All ApplicationsWB （1 imgs）

WB using PA5-20398
Western Blot with anti-IL-33 Polyclonal Antibody （PA5-20398）
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Western blot analysis of IL-33 in human lymph node tissue lysate with IL-33 antibody at （A） 1 and （B） 2 ug/mL.
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WB using PA5-20398
Western Blot with anti-IL-33 Polyclonal Antibody （PA5-20398）
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Western blot analysis of IL-33 in human lymph node tissue lysate with IL-33 antibody at （A） 1 and （B） 2 ug/mL.
... more >>

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